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ID cel-let-7 standard; RNA; CEL; 99 BP.
XX
AC MI0000001;
XX
DE Caenorhabditis elegans let-7 stem-loop
XX
RN [1]
RX PUBMED; 11679671.
RA Lau NC, Lim LP, Weinstein EG, Bartel DP;
RT "An abundant class of tiny RNAs with probabl e r eg ulatory roles in
RT Caenorhabditis elegans";
RL Science. 294:858-862(2001).
XX
RN [2]
RX PUBMED; 12672692.
RA Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yek ta S, Rhoades MW, Burge CB,
RA Bartel DP;
RT "The microRNAs of Caenorhabditis elegans";
RL Genes Dev. 17:991-1008(2003).
XX
RN [3]
RX PUBMED; 12747828.
RA Ambros V, Lee RC, Lavanway A, Williams PT, J ewe ll D;
RT "MicroRNAs and other tiny endogenous RNAs in C. e legans";
RL Curr Biol. 13:807-818(2003).
XX
RN [4]
RX PUBMED; 12769849.
RA Grad Y, Aach J, Hayes GD, Reinhart BJ, Churc h G M, Ruvkun G, Kim J;
RT "Computational and experimental identificati on of C. elegans microRNAs";
RL Mol Cell. 11:1253-1263(2003).
XX
RN [5]
RX PUBMED; 17174894.
RA Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nus ba um C, Ge H, Bartel DP;
RT "Large-scale sequencing reveals 21U-RNAs and ad di tional microRNAs and
RT endogenous siRNAs in C. elegans";
RL Cell. 127:1193-1207(2006).
XX
RN [6]
RX PUBMED; 19460142.
RA Kato M, de Lencastre A, Pincus Z, Slack FJ;
RT "Dynamic expression of small non-coding RNAs , i nc luding novel microRNAs
RT and piRNAs/21U-RNAs, during Caenorhabditis e leg an s development";
RL Genome Biol. 10:R54(2009).
XX
RN [7]
RX PUBMED; 20062054.
RA Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Lia ng TY, Pasquinelli AE, Yeo
RA GW;
RT "Comprehensive discovery of endogenous Argon aut e binding sites in
RT Caenorhabditis elegans";
RL Nat Struct Mol Biol. 17:173-179(2010).
XX
DR RFAM; RF00027; let-7.
DR WORMBASE; C05G5/12462-12364; .
XX
CC let-7 is found on chromosome X in Caenorhabd iti s elegans [1] and pairs to
CC sites within the 3' untranslated region (UTR ) o f target mRNAs, specifying
CC the translational repression of these mRNAs and t riggering the transition
CC to late-larval and adult stages [2].
XX
FH Key Location/Qualifiers
FH
FT miRNA 17..38
FT /accession="MIMAT0000001"
FT /product="cel-let-7"
FT /evidence=experimental
FT /experiment="cloned [1-3,5], No rt hern [1], PCR [4], Solexa
FT [6], CLIPseq [7]"
FT miRNA 56..80
FT /accession="MIMAT0015091"
FT /product="cel-let-7*"
FT /evidence=experimental
FT /experiment="CLIPseq [7]"
XX
SQ Sequence 99 BP; 26 A; 19 C; 24 G; 0 T; 30 ot her ;
uacacugugg auccggugag guaguagguu guauaguuug gaa ua uuacc accggugaac 60
uaugcaauuu ucuaccuuac cggagacaga acucuucga 99
// |
